Walter et Al – Effect of Enzogenol Supplementation on Cognitive, Executive and Vestibular/Balance Functioning in Chronic Phase of Concussion


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Effect of Enzogenol® Supplementation on Cognitive, Executive, and Vestibular/Balance Functioning in Chronic Phase of Concussion
A. Walter, K. Finelli, X. Bai, P. Arnett, T. Bream, P. Seidenberg, S. Lynch, B. Johnson, and S.
Slobounov
aPenn State Center for Sport Concussion, Pennsylvania State University, University Park, Pennsylvania; bDepartment 5 of Kinesiology, Pennsylvania State University, University Park, Pennsylvania; cSocial, Life, and Engineering Science Imaging Center, Pennsylvania State University, University Park, Pennsylvania; dDepartment of Psychology, Pennsylvania State University, University Park, Pennsylvania; eIntercollegiate Athletics, Pennsylvania State University, University Park, Pennsylvania

This study examined the feasibility of Enzogenol® as a potential treatment modality for concussed individuals with residual symptoms in the chronic phase. Forty-two student-athletes with history of sport-related concussion were enrolled, comparing Enzogenol® versus placebo. Testing was conducted using virtual reality (VR) and electroencephalography (EEG), with neuropsychological (NP) tasks primarily used to induce cognitive challenges. After six weeks, the Enzogenol® group showed enhanced frontal-midline theta, and decreased parietal theta power, indicating reduced mental fatigue. Subjects enrolled in the Enzogenol® group also self-reported reduced mental fatigue and sleep problems. This suggests that Enzogenol® has the potential to improve brain functioning in the chronic phase of concussion.

https://www.ncbi.nlm.nih.gov/m/pubmed/28452602/